Comprehensive Review on Vesicular Drug Delivery Systems

Abstract

Vesicular drug delivery system is a promising drug delivery system for the targeting of BCS class 2 & 4 drugs. It is superior to other drug delivery systems because of the high bioavailability, efficacy, & ease of preparation. Additionally, it was noted that because vesicular systems' lipidic components can penetrate and change the stratum corneum's intercellular lipid matrix, they can increase the penetration of medications into the layer. Although traditional vesicular systems like liposomes and niosomes have been around for a while, their limited physical stability causes problems including drug fusion, aggregation, and leakage. It was discovered that the transdermal drug delivery method was a useful means of resolving issues with traditional oral dose forms, including low bioavailability, frequent high dosage, and untargeted drug activity. However, the stratum corneum functions as a strong barrier that lowers drug permeability and, thus, the bioavailability of big molecules and hydrophilic medications. Recent years have seen the development of novel, adaptable non-ionic surfactant-based vesicles, such as niosomes, proniosomes, transferosomes, pharmacosomes, etc., enabling effective medication delivery via the skin.