Synergistic Potential and Nano-Delivery of Neem Extract in Oral Oncology

Abstract

Oral cancer continues to pose a major global health challenge, with current treatment options often leading to considerable side effects and inconsi stent therapeutic success. Recently, there has been growing interest in natural compounds assafer and more effective alternatives or adjuncts to conventional treatments. Neem (Azadirachta indica), a widely recognized medicinal plant, exhibits potent anticancer, antioxidant, and anti-inflammatory activities, making it a strong candidate for use in oral cancer management. This study investigates the combined potential of neem extract and nanotechnology-based delivery systems. The conventional use of plant-derived compounds is often limited by issues such as poor solubility, reduced bioavailability, and inadequate targeting. Incorporating neem extract into nanoscale carriers can help address these challenges by improving targeted delivery to cancerous cells while reducing harm to normal tissues. Nanocarrier systems also enhance the stability and allow controlled release of neem’s active constituents, thereby increasing their therapeutic effectiveness. Furthermore, the synergistic interaction between neem bioactives and nano-delivery platforms may strengthen anticancer effects, such as suppressing tumor growth, triggering apoptosis, and limiting cancer spread. However, limited clinical translation highlights the need for further trials to validate its therapeutic potential.