Role of Advanced Pharmaceutics and Digital Technologies in Future Healthcare: From Conventional Dosage Forms to Intelligent Drug Delivery

Abstract

The rapid evolution of pharmaceutical sciences, coupled with advancements in digital technologies, has significantly transformed modern healthcare and drug delivery paradigms. Conventional dosage forms, while effective, often face limitations such as poor bioavailability, lack of site specificity, variable therapeutic outcomes, and reduced patient compliance. These challenges have driven the development of advanced pharmaceutics, encompassing controlled and targeted drug delivery systems, nanotechnology-based carriers, and stimuli-responsive formulations. In parallel, the integration of digital technologies—including artificial intelligence, machine learning, big data analytics, and the Internet of Things—has further accelerated innovation in drug design, formulation optimization, and personalized medicine. This review critically examines the transition from traditional dosage forms to intelligent drug delivery systems, highlighting the role of advanced pharmaceutics in improving therapeutic efficacy and safety. Emphasis is placed on nanocarriers, smart polymers, and bio-responsive systems that enable controlled and targeted drug release. Additionally, the application of digital tools in formulation development, predictive modeling, and real-time patient monitoring is discussed, demonstrating their potential to enhance decision-making throughout the drug development lifecycle. The convergence of pharmaceutics and digitalization has led to the emergence of intelligent drug delivery platforms capable of sensing physiological conditions and adjusting drug release accordingly. Furthermore, this review addresses current challenges related to manufacturing, regulatory approval, data security, and clinical translation of digitally enabled drug delivery systems. Finally, future perspectives are presented, underscoring the importance of interdisciplinary collaboration and regulatory adaptation to fully realize the potential of intelligent drug delivery in personalized and precision healthcare.