Curcuma longa (Turmeric) in Breast Cancer: Modulation of p53, NF-κB, and PI3K/Akt Pathways

Authors

  • Ashwini Badhe Swalife Biotech Ltd North Point House, North Point Business Park, New Mallow Road, Cork (Republic of Ireland) Author
  • Dr. Pravin Badhe Swalife Biotech Ltd North Point House, North Point Business Park, New Mallow Road, Cork (Republic of Ireland) Author

Keywords:

Curcuma longa, turmeric, curcumin, breast cancer, p53 pathway, NF-κB, PI3K/Akt, chemosensitisation

Abstract

Background:
Breast cancer is the most common malignancy among women worldwide, accounting for approximately 2.3 million new cases and 670,000 deaths in 2022. Projections indicate a 38% increase in incidence and 68% rise in mortality by 2050 if current trends persist. Dysregulation of key signaling pathways—including tumor suppressor p53, pro-inflammatory NF-κB, and pro-survival PI3K/Akt—drives tumor progression, metastasis, and therapeutic resistance. Natural compounds such as curcumin from Curcuma longa (turmeric) have gained prominence for their multitargeted anticancer potential.

 

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Published

2025-10-31

Issue

Vol. 1 No. 07 (2025)

Section

Articles