Exploring DNA Damage Responses in Cancer Therapy: Mechanisms, Strategies, and Future Directions
Keywords:
DNA damage, Repair, Cancer therapy, Mechanisms, Strategies.Abstract
DNA disruption is a pivotal event in carcinogenesis, emanating from intrinsic cellular processes and external environmental agents. When inadequately repaired, it leads to hereditary perturbation and oncogenic transformation. This review presents an extensive outline of the molecular mechanisms underlying DNA impairment and repair, focusing on their application in cancer therapy.