Next-Generation Multifunctional Stimuli-Responsive Self-Healing Hydrogels for Precision Therapeutics and Advanced Regenerative Tissue Engineering

Abstract

This report provides a comprehensive structure and content outline for a review paper on next-generation multifunctional stimuli-responsive self-healing hydrogels. It begins with an introduction covering the evolution from conventional to smart hydrogels, the concepts of stimuli-responsiveness and self-healing, and their importance in precision therapeutics and tissue engineering. The core sections detail the fundamentals of self-healing mechanisms and stimuli-responsive principles, the materials (natural/synthetic polymers, nanomaterials) and advanced engineering/fabrication strategies used. It extensively covers biomedical applications in precision therapeutics (e.g., controlled drug delivery, cancer therapy) and regenerative tissue engineering (e.g., skin, bone, neural, cardiac repair). The report concludes with discussions on emerging functionalities (e.g., thernostics, AI- assisted design), biological safety, clinical translation challenges, and future perspectives, fully addressing the user's specified title and sub-headings.